ITCM provides several signature search methods to find TCM small molecules that give rise to similar (or opposing) expression signatures.
Please follow the instructions below to enter the content to get the results.
Please notice that some methods take a few minutes to return results.
Note:
1. web proxy may disable returning results, please close web proxy before query.
2. Results will be stored in the server for 30 days and will be returned immediately when you resubmit the data.
3. All tasks will be running in the server upon successful submission, You may wait, or resubmit later for results enquiry.
4. Incorrect data format may not yield results.
ITCM provides six signature search methods to query TCM small molecules that give rise to similar (or opposing) expression signatures, user can select method, then input up- and down- regulated geneset(at leaset 10 vaild genes) or geneset with logFC to get results.
logFC Matrix:
SS_All integrates rankings of 496 small molecules across six methods using Robust Rank Aggregation.In general, small molecules that rank high in most methods are more likely to be therapeutic.
Note that the user needs to select the direction (up or down) to rank small molecules.
For disease-related logFC, please select "down" direction.
For drug-related logFC, please select "up" direction.
logFC Matrix: